MOTS-C

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino acid peptide encoded within the mitochondrial genome, making it one of the few known mitochondria-derived peptides (MDPs).

MOTS-c is unique because it is encoded by mitochondrial DNA rather than nuclear DNA, representing a form of mitochondrial-nuclear communication. It is released into the bloodstream where it acts as a signaling molecule that regulates metabolic homeostasis.

In preclinical research, MOTS-c has demonstrated effects on glucose regulation, fatty acid metabolism, and AMPK activation. It has also shown exercise-mimetic properties, with levels increasing during physical activity. Studies in aged mice showed improvements in physical capacity and metabolic function.

MOTS-c is not approved by the FDA for any medical use. All products are sold strictly for laboratory and research purposes only.